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The absorption and efficacy of glutathione supplements depend on several factors, including whether they are taken on an empty stomach or with food, the influence of other supplements or medications, individual differences in metabolism and bioavailability, and the role of glutathione precursors

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Furthermore, epidemiological prospective studies have identified high plasma levels of IGF-1 as a potential risk factor for several malignancies (Hankinson et al, 1998)