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Superoxide combines with NO to form peroxynitrite that oxidizes BH4 and destabilizes eNOS to produce more superoxide and enhancing the development of oxidative stress.[33] Angiotensin-II also, as a potent activator of NADPH oxidase, contributes to the production of ROS

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[DOI] [PubMed] [Google Scholar] [44].Putt DA, Zhong Q, Lash LH Adaptive changes in renal mitochondrial redox status in diabetic nephropathy