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THE STRUCTURE AND FUNCTION OF URATE TRANSPORTERS Uric acid crosses through the glomerulus freely, then most is reabsorbed by proximal tubular urate transporters and only a small portion of it is secreted back into the filtrate via the late proximal tubule [19]

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Experimental models of alcohol exposure have shown elevated levels of ER stress markers, including CHOP, ATF4 and GRP78, in the brain, correlating with neuronal loss and impaired cognitive function [16,20]