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The primers used for RTPCR were ordered from Integrated DNA Technologies (Coralville, Iowa, USA) and the primer sequences are as follows: Human & mouse ERα: sense 5′-CCTGGACAAGATCACAG-3′ antisense 5′-AGCAGGTCATAGAGGGG-3′, Human & mouse GPR30: sense 5′-CCTGTACTTCATCAACCTG-3′ antisense 5′-TCATCCAGGTGAGGAAG-3′, Human & mouse GAPDH: sense 5′-ACTTTGTCAAGCTCATTTCC-3′ antisense 5′-TCTTACTCCTTGGAGGCCAT-3′, Mouse Nrf2: sense 5′-CAAGACTTGGGCCACTTAAAAGAC-3′ antisense 5′-AGTAAGGCTTTCCATCCTCATCAC-3′, Mouse NQO1: sense 5′-AGCTGGAAGCTGCAGACCTG-3′ antisense 5′-CCTTTCAGAATGGCTGGCA-3′, Mouse HMOX1: sense 5′-GCTAGCCTGGTGCAAGATACTG-3′ antisense 5′-CACATTGGACAGAGTTCACAGC-3′, Mouse ABCC1: sense 5′-GCGCTGTCTATCGTAAGGCT-3′ antisense 5′-AGAGGGGCTGACCAGATCAT-3′, Mouse ABCG2: sense 5′-TGGACTCAAGCACAGCGAAT-3′ antisense 5′-ATCCGCAGGGTTGTTGTAGG-3′, Mouse ABCC3: sense 5′-GGGCTCCAAGTTCTGGGAC-3′antisense 5′-CCGTCTTGAGCCTGGATAAC-3′, Mouse CypA: sense 5′-CACCGTGTTCTTCGACATCAC -3′ antisense 5′-CCAGTGCTCAGAGCTCGA AAG -3′, Mouse SOD1: sense 5 ‘-CCA GTG CAG GAC CTC ATT TT-3′ antisense 5′-CAC CTT TGC CCA AGT CAT CT-3′, Mouse HPRT: sense 5′-GCTGGTGAAAAGGACCTCT-3′ antisense 5′-CACAGGACTAGAACACCTGC -3′
