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found that NRF2 suppresses both lipid biosynthesis and desaturation genes in the mouse liver, including NADPH-utilizing enzymes fatty acid synthase (FASN) and stearoyl-CoA desaturase 1 (SCD1) [30]

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To determine whether these transcriptomic changes were reflected at the metabolic level, we quantified β-hydroxybutyrate, a terminal product of β-oxidation, in both cell lysates and culture supernatants