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Intravenous LC supplementation may be more efficacious if renal function is not affected, as above 95 % of LC filtered via glomeruli is stored, and excessive exogenous LC is rapidly eliminated

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3 Leucovorin Calcium Supplementation and ASD Given this potential link between folate and ASD symptoms, it was hypothesized that folate supplementation may improve symptoms of ASD, especially in those with verbal communication and language impairment