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Denaturation unfolds the protein structure, potentially destroying the binding sites that make retatrutide effective at its three target receptors

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In addition, the MRP1 substrates taurolithocholate-3-sulphate and 17β-estradiol 17-(β-D-glucuronide) are able to block the CFTR channel, suggesting that MRP1 and CFTR share some binding properties (Linsdell and Hanrahan, 1999)