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NAD + levels increase under conditions that increase lifespan and healthspan, such as dietary restriction and exercise, and decrease during ageing or under conditions that decrease lifespan and healthspan, such as a high-fat diet, which supports the working model that decreased NAD + levels might contribute to the ageing process [57]

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A pilot study involving 16 patients with distal IBD reported a mean 60% reduction in disease severity after 12 weeks of rectal GHK-Cu treatment, as assessed by endoscopic, histopathological, and symptomatic evaluations (Pickart, 2008)