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First, the phase 2 obesity trial (NCT04881760, 338 adults, 48 weeks) tested 2 mg and 4 mg starting doses and found that the lower start partially mitigated gastrointestinal events, which the authors describe as dose related and mostly mild to moderate (Jastreboff et al., NEJM 2023)

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Durée de la cure:2 mois | 240 gélules | -5%

The meta-analysis by Talenezhad et al