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Glutathione peroxidase 1 (GPx1) reduces hydrogen peroxide generated after exposure to certain drugs, by oxidizing GSH to its disulfide form GSSG

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Treatment with N-acetyl-L-cysteine, an antioxidant, or adenovirus-mediated overexpression of GPx1 attenuated the upregulation of adhesion molecules, confirming the role for GPx-1 suppression and hydrogen peroxide accumulation in these proinflammatory responses