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The B12-conjugated GLP-1 agonist maintained comparable blood sugar control but with significantly better tolerance, less nausea, and fewer emetic episodes in both rat and mammalian models

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All cysteine mutants could be expressed and purified, with yields between 3.2 and 17.1 mg/L (median 6.9 mg/L) of purified protein from 50 mL expression cultures