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As GST isozymes (in particular GST π ) are frequently upregulated in many solid tumors and lymphomas, prodrugs activated by GST-mediated catalysis have become a viable drug design concept

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Despite the “Approved” column for infectious diseases being vacant, the “Phase 3” and “Preclinical” categories are witnessing unprecedented investment in ID-ADCs, indicating a strategic shift in the field from oncology imitation (Onc-ADCs) to pathogen-focused, infection-targeted development