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✍Similarly to MBS, GLP-1RA treatment can lead to substantial lean body mass (LBM) loss, consisting mainly of skeletal muscle tissue, which may in turncompromise muscle function and performance, but the evidence is scarce ✍Recent GLP-1RA trials have predominantly focused on quantification of weight loss, adverse effects, and clinical outcomes, whereas physical functioning outcomes associated with LBM loss remain largely unexamined ✍Therefore, the authors emphasize the importance of including physical function outcome measures in GLP-1RA trials focusing on weight loss

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Circulation 26, 121–132